Pharmacogenomic considerations for customizing warfarin therapy in the orthopedic patient.
نویسندگان
چکیده
Ms Rhee and Dr Smith are from the University of Kentucky College of Pharmacy, and Drs Walsh, Lewis, and Davis are from UK Healthcare, Lexington, Kentucky. Ms Rhee and Drs Walsh, Lewis, Davis, and Smith have no relevant fi nancial relationships to disclose. Correspondence should be addressed to: Kelly M. Smith, PharmD, BCPS, FASHP, FCCP, University of Kentucky College of Pharmacy, 789 S Limestone, 114H, Lexington, KY 40536 ([email protected]). doi: 10.3928/01477447-20100924-19 The increasing availability of genetic tests is allowing for a more accurate and customized method of dosing warfarin.
منابع مشابه
Pharmacogenomic trial design: use of a PK/PD model to explore warfarin dosing interventions through clinical trial simulation.
OBJECTIVE Variants of two genes, CYP2C9 and VKORC1, explain approximately one third of variability in warfarin maintenance dose requirements. However, the clinical utility of using this information in addition to clinical and demographic data ('pharmacogenomic-guidance') is unclear, as few comparative clinical trials have been conducted to date. The objective of this study was to explore the in...
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عنوان ژورنال:
- Orthopedics
دوره 33 11 شماره
صفحات -
تاریخ انتشار 2010